Water → ethyl 1H-pyrazol-5-ylcarbamothioylcarbamate

HRID 2239830Notes

Reaction equation

HRID 2239830 reaction equation
[CH2:1]([O:3][C:4]([N:6]=[C:7]=[S:8])=[O:5])[CH3:2].[NH2:9][C:10]1[CH:14]=[CH:13][NH:12][N:11]=1.O>CC(C)=O>[NH:11]1[C:10]([NH:9][C:7]([NH:6][C:4](=[O:5])[O:3][CH2:1][CH3:2])=[S:8])=[CH:14][CH:13]=[N:12]1

Participants

5

Reactant 3

HCID 962WaterHCID 85320Ethyl isothiocyanatoformateHCID 178418806HCID 178418806, compound

Product 1

HCID 21828293ethyl 1H-pyrazol-5-ylcarbamothioylcarbamateYield 90%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Ethoxycarbonyl isothiocyanate (3.16 g, 24.07 mmol) was added to 3-aminopyrazole (Aldrich) (2.0 g, 24.07 mmol) in acetone (20 mL). The reaction mixture was stirred at room temperature for 1 hour. Then cold water (100 mL) was added to the reaction mixture. The solid precipitate was collected through filtration, washed with water (50 mL), and then air dried to give 4.64 g (90%) of ethyl 1H-pyrazol-5-ylcarbamothioylcarbamate.

Workup

  1. filtrationThe solid precipitate was collected through filtration
  2. washwashed with water (50 mL)
  3. customair dried

Sources & evidence

ORD record
ord-5e5c5f349cde45b19ef4e904daf0d8fa
Source dataset
uspto-grants-2010_05
Patent number
US07723336B2

Reaction notes

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