Sodium Hydroxide → HCID 178518767, compound

HRID 2239831Notes

Reaction equation

HRID 2239831 reaction equation
[NH:1]1[C:5]([NH:6][C:7]([NH:9][C:10](=[O:14])OCC)=[S:8])=[CH:4][CH:3]=[N:2]1.[OH-].[Na+]>>[S:8]=[C:7]1[NH:9][C:10](=[O:14])[N:1]2[N:2]=[CH:3][CH:4]=[C:5]2[NH:6]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 21828293ethyl 1H-pyrazol-5-ylcarbamothioylcarbamate

Product 1

HCID 178518767HCID 178518767, compoundYield 91.1%

Procedure

Ethyl 1H-pyrazol-5-ylcarbamothioylcarbamate (4.64 g, 21.68 mmol) from 1a was added to 2N NaOH solution (51 mL). The reaction mixture was stirred at room temperature for 2½ hours and then acidified with 2NH2SO4. The resulting precipitate was collected by vacuum filtration, washed with water followed by diethyl ether, and then air dried to give 3.32 g (82%) of 2-thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one as a pale yellow solid.

Workup

  1. filtrationThe resulting precipitate was collected by vacuum filtration
  2. washwashed with water
  3. customair dried

Sources & evidence

ORD record
ord-58fabe2fe1f54a1caf3daae64d2bc3a9
Source dataset
uspto-grants-2010_05
Patent number
US07723336B2

Reaction notes

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