Water → HCID 68484250, compound

HRID 2239834Notes

Reaction equation

HRID 2239834 reaction equation
[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[CH:8][CH:9]=1.Cl[C:12]1[N:17]2[N:18]=[CH:19][CH:20]=[C:16]2[N:15]=[C:14]([S:21][CH3:22])[N:13]=1.O>O1CCOCC1>[CH2:2]([O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:12]2[N:17]3[N:18]=[CH:19][CH:20]=[C:16]3[N:15]=[C:14]([S:21][CH3:22])[N:13]=2)=[CH:6][CH:5]=1)[CH3:1]

Participants

5

Reactant 3

HCID 962WaterHCID 90764-EthoxyanilineHCID 129161154-Chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine

Product 1

HCID 68484250HCID 68484250, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

p-Phenetidine (3.09 g, 22.51 mmol) was added to a mixture of 4-chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine (300 mg, 1.5 mmol) from 1d in 1,4-dioxane (6 mL). The mixture was heated to 100° C. for ½ hour. Water (15 mL) was then added to the reaction mixture and the resulting precipitate was collected by vacuum filtration, washed with cold water and hexane, and then air dried to give 360 mg (80%) of N-(4-ethoxyphenyl)-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-amine.

Workup

  1. filtrationthe resulting precipitate was collected by vacuum filtration
  2. washwashed with cold water and hexane
  3. customair dried

Sources & evidence

ORD record
ord-4255c920465040f38394a8c79eb77605
Source dataset
uspto-grants-2010_05
Patent number
US07723336B2

Reaction notes

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