Triethylamine → 6-chloro-N-(4-ethoxyphenyl)-3-fluoroimidazo[1,2-b]pyridazin-8-amine

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	4-Ethoxyaniline	HCID 9076	—
Reactant	8-Bromo-6-chloro-3-fluoroimidazo[1,2-b]pyridazine	HCID 86611742	—
Solvent	Ethanol	HCID 702	—
Product	6-chloro-N-(4-ethoxyphenyl)-3-fluoroimidazo[1,2-b]pyridazin-8-amine	HCID 86611741	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

p-Phenetidine (0.044 ml, 0.34 mmol) and triethylamine (0.1 ml, 0.75 mmol) were added to a mixture of 8-bromo-6-chloro-3-fluoroimidazo[1,2-b]pyridazine (0.085 g, 0.34 mmol) from 1a in EtOH (1.7 mL). The mixture was heated to 80° C. and stirred for 16 hors. The solution was then concentrated in vacuo to give crude 6-chloro-N-(4-ethoxyphenyl)-3-fluoroimidazo[1,2-b]pyridazin-8-amine.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07723336B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-30c8daaffe464b6887219b9bf2f8bdca
Source note	uspto-grants-2010_05