HCID 58812135, compound → HCID 58812092, compound

Participants

Reaction Steps

A solution of toluene-4-sulfonic acid 2-(3-benzenesulfonylmethyl-4-nitro-phenoxy)-ethyl ester (13.1 g, 26.7 mmol) in THF (350 mL) and ethanol (250 mL) was added to 10% palladium on carbon (5.8 g) and hydrogenated on the Parr apparatus with for one hour (starting pressure of 30-40 psi.). The mixture was filtered over Celite, concentrated and dried in vacuo at 80° C. for 30 minutes to yield toluene-4-sulfonic acid 2-(4-amino-3-benzenesulfonylmethyl-phenoxy)-ethyl ester as a light yellow solid (11.7 g, 95.1%): MP: 144-6° C.; Mass spectrum (+EI, [M+H]+) m/z 462.

Provenance & Evidence