Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

A mixture of 6-(2-azido-ethoxy)-3-(naphthalene-1-sulfonyl)-1H-indazole (0.17 g, 0.45 mmoles) and 10% Pd/C in THF (2 mL), and methanol (8 mL) was hydrogenated in a Parr hydrogenation bottle (250 mL) at 52 lb/in2 for 2 hours. The mixture was filtered through Celite, and the filtrate was concentrated under vacuum. The crude product was recrystallized from CH2Cl2/hexane, 1M HCl in ether (0.4 mL, 0.4 mmoles) was added, then dried, to afford the title compound as an off-white HCl salt (0.15 g, 0.4 mmoles), MS: (ES+) 368 [M+H]+

Provenance & Evidence