Pyridine → HCID 178483343, compound

Participants

Reaction Steps

2-[3-(Phenylsulfonyl)-1H-indazol-7-yl]ethyl 4-methylbenzenesulfonate To a solution of 2-[3-(phenylsulfonyl)-1H-indazol-7-yl]ethanol (0.64 g, 2.12 mmol) in anhydrous dichloromethane (30 mL) at 0° C. was added pyridine (0.43 mL) and toluenesulfonyl chloride (0.475 g, 2.5 mmol). The solution was stirred for 12 hours at room temperature. The mixture was concentrated in vacuo and taken up in ethyl acetate (30 mL). The organic layer was washed with 2 M HCl, (2×25 mL), brine, dried (MgSO4), filtered and concentrated under reduced pressure. Silica gel chromatography (50% ethyl acetate/petroleum ether) gave the title compound as a white foam (0.9 g, 93%). Mp: 61-64° C. MS (ES−): 455 (M−H) Step 7

Provenance & Evidence