HRID2240143

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CC2(CCNCC2)c2cc(F)ccc21

HCID49760960

tert-Butyl 5-fluorospiro[indole-3,4'-piperidine]-1(2H)-carboxylate

C17H23FN2O2

HCID59305139

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CC2(CCN(CC(O)C3CCN(C(=O)OCc4ccccc4)CC3)CC2)c2cc(F)ccc21

HCID66938096

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度: 95 °C

PROCEDURE

实验过程

Phenylmethyl 4-(2-oxiranyl)-1-piperidinecarboxylate (990 mg) was added to a solution of 1,1-dimethylethyl 5-fluorospiro[indole-3,4′-piperidine]-1(2H)-carboxylate (1.16 g) in EtOH (20 mL). The reaction was heated to 95° C. for 7 h and then stirred at room temperature overnight. The solvent was removed and the title compound was obtained as crude oil. MS (ES) m/e 568 [M+H]+.

WORKUP

后处理

customThe solvent was removed

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e8e548bf9a2d44ceb770fd9f0fd5d25c
来源数据集: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07723350B2
来源说明: uspto-grants-2010_05

反应 SMILES

[O:1]1[CH2:3][CH:2]1[CH:4]1[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:11])[CH2:6][CH2:5]1.[F:20][C:21]1[CH:22]=[C:23]2[C:29]3([CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)[CH2:28][N:27]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[C:24]2=[CH:25][CH:26]=1>CCO>[F:20][C:21]1[CH:22]=[C:23]2[C:29]3([CH2:34][CH2:33][N:32]([CH2:3][CH:2]([OH:1])[CH:4]4[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][C:14]5[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=5)=[O:11])[CH2:6][CH2:5]4)[CH2:31][CH2:30]3)[CH2:28][N:27]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[C:24]2=[CH:25][CH:26]=1