HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(3-fluorophenyl)(hydroxy)methyl]-4-methoxy-N-methylbenzamide → 2-(3-fluorobenzyl)-4-methoxy-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(3-fluorophenyl)(hydroxy)methyl]-4-methoxy-N-methylbenzamide | HCID 68514005 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(3-fluorobenzyl)-4-methoxy-N-methylbenzamide | HCID 68509841 | — |
Reaction Steps
To a solution of 2-[(3-fluorophenyl)(hydroxy)methyl]-4-methoxy-N-methylbenzamide (500 mg) in methanol was added 500 mg of Pd/C (10%). The reaction was stirred overnight under H2 (1 atm), then filtered through celite and concentrated to give 2-(3-fluorobenzyl)-4-methoxy-N-methylbenzamide, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723352B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-a467d4242c0345a49538bc6e9dab3154 |
| Source note | uspto-grants-2010_05 |