HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one → 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one | HCID 68509193 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one | HCID 11278230 | — |
Reaction Steps
A mixture of 3-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one (0.333 g) and 48% HBr (30 mL) was heated at reflux for 8 h. The reaction was concentrated to give 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one as a brown solid, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723352B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-27e825ed0f8b4377be7266908b0b8d4f |
| Source note | uspto-grants-2010_05 |