tert-Butyl N-(2-bromoethyl)carbamate → HCID 68508262, compound

HRID 2240206Notes

Reaction equation

HRID 2240206 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([CH2:14]CCN1C(=O)C3C(=CC=CC=3)C1=O)[C:7]([CH3:28])=[C:6]2[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.[C:35]([NH:42][CH2:43]CBr)([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([CH2:14][CH2:43][NH:42][C:35](=[O:36])[O:37][C:38]([CH3:41])([CH3:40])[CH3:39])[C:7]([CH3:28])=[C:6]2[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 4103526tert-Butyl N-(2-bromoethyl)carbamateHCID 68510088HCID 68510088, compound

Product 1

HCID 68508262HCID 68508262, compound

Procedure

Following the procedure for 2-[3-(6-methoxy-3-methyl-1-oxo-4-phenylisoquinolin-2(1H)-yl)propyl]-1H-isoindole-1,3(2H)-dione, using 2-(Boc-amino) ethyl bromide in place of 3-phthalimido-1-bromopropane, tert-butyl 2-(6-methoxy-3-methyl-1-oxo-4-phenylisoquinolin-2(1H)-yl)ethylcarbamate was obtained.

Sources & evidence

ORD record
ord-a40c12eddbf04dbdb916a2a67e034018
Source dataset
uspto-grants-2010_05
Patent number
US07723352B2

Reaction notes

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