Water → HCID 59305024, compound

Participants

Reaction Steps

147 mg (650 μmol) of tin(II) chloride dihydrate are added to a solution of 40 mg (130 μmol) of 3-chloro-N-(2-fluoro-4-nitrophenyl)-1H-pyrrolo[2,3-b]pyridine-4-amine in 2.50 ml of DMF, and this solution is stirred at RT overnight. 5 ml of water are then added, and the pH is adjusted to 10 using saturated sodium bicarbonate solution. After filtration through Celite, the Celite is washed with 40 ml of ethyl acetate. The aqueous phase of the filtrate is extracted twice with 10 ml of ethyl acetate. The combined organic phases are washed in each case twice with 5 ml of water and 5 ml of saturated sodium chloride solution and dried with sodium sulfate. Concentration under reduced pressure affords the target compound which is reacted further without purification.

Provenance & Evidence