Potassium Carbonate → HCID 59305015, compound

Participants

Reaction Steps

A solution of 80 mg (210 μmol) of 3-bromo-4-nitro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine, 27 mg (210 μmol) of trimethylboroxine, 25 mg (20 μmol) of tetrakis(tri-phenylphosphine)palladium and 103 mg (640 μmol) of potassium carbonate in 2.00 ml of degassed DMF is stirred in a sealed pressure vessel at 110° C. for 6 h and then at RT overnight. The suspension is then filtered through an Extrelut silica gel cartridge, the cartridge is washed with a mixture of dichloromethane/methanol 1:1 and the filtrate is concentrated under reduced pressure. The residue is purified by preparative RP-HPLC.

Provenance & Evidence