Potassium Hydroxide → HCID 11659835, compound

Participants

Reaction Steps

2.10 g (5.30 mmol) of ethyl [4-(dibenzylamino)-2,6-difluorophenyl]carbamate are dissolved in 40 ml of ethanol. 3.0 g (53 mmol) of powdered potassium hydroxide are added, and the mixture is heated at reflux for 20 hours. The solvent is then removed, and water and dichloromethane are added to the residue. The organic phase is separated off, washed three times with water, dried over sodium sulfate and concentrated. The residue is taken up in ethyl acetate and clarified over activated carbon. Using pentane, crystals are obtained which are filtered off with suction.

Provenance & Evidence