HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-nitro-1H-pyrrolo[2,3-b]pyridine → 1-Methyl-1H-pyrrolo[2,3-b]pyridin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-nitro-1H-pyrrolo[2,3-b]pyridine | HCID 59305025 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Tetrahydrofuran ethanol | HCID 21873804 | — |
| Product | 1-Methyl-1H-pyrrolo[2,3-b]pyridin-4-amine | HCID 55289412 | — |
Reaction Steps
300 mg (1.69 mmol) of 1-methyl-4-nitro-1H-pyrrolo[2,3-b]pyridine are dissolved in a mixture of 20 ml of ethanol/THF (1:1). 38 mg (0.17 mmol) of platinum(IV) oxide are added, and the mixture is hydrogenated in a hydrogen atmosphere at atmospheric pressure overnight. The mixture is filtered through Celite and the solvent is removed under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723347B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-0345f99d768646219f4c1f289a99ff1a |
| Source note | uspto-grants-2010_05 |