2-Chloro-4-nitroaniline → HCID 59304984, compound

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-4-nitroaniline	HCID 8492	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl	HCID 11155794	—
Reactant	4-Chloro-1H-pyrrolo[2,3-b]pyridine	HCID 11389493	—
Catalyst	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
Solvent	tert-Butanol	HCID 6386	—
Product	HCID 59304984	HCID 59304984	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

Variant B: A mixture of 200 mg (1.31 mmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine, 678 mg (3.93 mmol) of 2-chloro-4-nitroaniline, 60 mg (0.07 mmol) of tris(dibenzylideneacetone)dipalladium, 62 mg (0.13 mmol) of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine and 399 mg (2.88 mmol) of potassium carbonate and 2.50 ml of degassed tert-butanol is stirred in a sealed pressure vessel at 100° C. for 3 h.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07723347B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-f42f7cfcb8d047c5b303fb7e3b54a553
Source note	uspto-grants-2010_05