HCID 59304984, compound → HCID 59305028, compound

Participants

Reaction Conditions

Reaction Steps

Variant B: A solution of 10 mg (60 μmol) of iron(III) chloride in 2.40 ml of water and then 38 mg (170 μmol) of powdered iron are added to a solution of 16 mg (60 μmol) of N-(2-chloro-4-nitrophenyl)-1H-pyrrolo[2,3-b]pyridine-4-amine in 3.60 ml of ethanol. After 3 h of stirring at 80° C., the suspension is filtered through kieselguhr and the kieselguhr is washed with ethanol. The solvent is removed under reduced pressure and the residue is dissolved in a mixture of dichloromethane/methanol 10:1 and crudely purified by column filtration on silica gel. This gives 22 mg of a crude product which is directly reacted further without further purification.

Provenance & Evidence