Water → HCID 59305016, compound

Participants

Reaction Steps

5 ml of a 20% strength aqueous sodium hydroxide solution are added to a solution of 390 mg (0.66 mmol) of N4,N4-dibenzyl-2,6-difluoro-N1-{3-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}benzene-1,4-diamine in 15 ml of ethanol, and the mixture is stirred overnight. The reaction solution is then poured into a mixture of water and ethyl acetate and the aqueous phase is extracted two more times with ethyl acetate. Purification by preparative HPLC affords the target compound.

Provenance & Evidence