反应详情

200 mg (0.38 mmol) of 2,2,2-trifluoro-N-{3-fluoro-4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]phenyl}acetamide and 68.5 mg (0.38 mmol) of N-bromo-succinimide in 8 ml of carbon tetrachloride are heated at reflux for 20 min. After cooling, the mixture is diluted with water and dichloromethane and extracted. The organic phase is separated off, dried over sodium sulfate and concentrated under reduced pressure.

1. temperatureat reflux for 20 min
2. temperatureAfter cooling
3. extractionextracted
4. customThe organic phase is separated off
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure