Iodine → 4-Chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine

Participants

Reaction Conditions

Reaction Steps

250 g (1.64 mol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine and 328 g (5.85 mol) of powdered potassium hydroxide are initially charged in 3000 ml of DMF and cooled to 0° C. With cooling, a solution of 416 g (1.64 mol) of iodine in 3000 ml of DMF is added dropwise to this suspension, and the mixture is, after the end of the addition, stirred at 0° C. for 4 h. To bring the reaction to completion, the mixture is added with stirring to ice-water and the solid formed is filtered off with suction and then dried under high vacuum. This gives 403 g (88% of theory) of the title compound as a solid.

Provenance & Evidence