Potassium Carbonate → HCID 59305023, compound

Participants

Reaction Steps

A solution of 170 mg (0.485 mmol) of 4-chloro-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-pyrrolo[2,3-b]pyridine, 91 mg (0.58 mmol) of 2-fluoro-4-nitroaniline, 31 mg (0.035 mmol) of tris(dibenzylideneacetone)dipalladium, 33 mg (0.07 mmol) of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine and 100 mg (0.72 mmol) of potassium carbonate in 3.00 ml of degassed tert-butanol is stirred in a sealed pressure vessel at 100° C. for 3 h. After cooling to RT, the reaction mixture is filtered through kieselguhr, the kieselguhr is washed with ethyl acetate and the filtrate is freed from the solvent. The residue is purified by preparative HPLC.

Provenance & Evidence