HCID 59305030, compound → HCID 59305014, compound

HRID 2240259Notes

Reaction equation

HRID 2240259 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[C:13]2[C:20]([C:21]([F:24])([F:23])[F:22])=[CH:19][NH:18][C:14]=2[N:15]=[CH:16][CH:17]=1.[H][H]>C(O)C.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]2[NH:18][CH:19]=[C:20]([C:21]([F:24])([F:22])[F:23])[C:13]=12

Participants

5

Reactant 2

HCID 59305030HCID 59305030, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59305014HCID 59305014, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10 mg of 10% palladium-on-carbon are added to a solution of 129 mg (0.38 mmol) of N-(2-fluoro-4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4-amine in 5 ml of ethanol, and the suspension is stirred in a hydrogen atmosphere at atmospheric pressure overnight. The suspension is filtered through kieselguhr and the kieselguhr is washed with ethanol. The filtrate is concentrated. The product is purified by preparative HPLC.

Workup

  1. filtrationThe suspension is filtered through kieselguhr
  2. washthe kieselguhr is washed with ethanol
  3. concentrationThe filtrate is concentrated
  4. customThe product is purified by preparative HPLC

Sources & evidence

ORD record
ord-bfe830d826d0473595799076e62b3040
Source dataset
uspto-grants-2010_05
Patent number
US07723347B2

Reaction notes

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