Hydrochloric Acid → HCID 59305009, compound

Participants

Reaction Conditions

Reaction Steps

125 mg (0.56 mmol) of N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzene-1,4-diamine and 118 mg (0.72 mmol) of 4,6-dichloropyrimidine-2-amine are suspended in 5 ml of water. 0.72 ml of 1 M hydrochloric acid are added, and the mixture is heated at 100° C. overnight. Using 1N aqueous sodium hydroxide solution, the suspension is then adjusted to pH 10, resulting in the precipitation of crystals. The solid is filtered off and washed with water. The crude product is purified by column chromatography on silica gel (mobile phase: dichloromethane/methanol (7 M ammonia) 100:1 to 10:1).

Provenance & Evidence