3-Quinuclidinol, (-)- → (R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide

Participants

Reaction Steps

A solution comprising 2-bromo-N-isoxazol-3-yl-acetamide (0.975 g, 4.72 mmol), (R)-1-aza-bicyclo[2.2.2]octan-3-ol (0.549 g, 4.32 mmol) in chloroform/acetonitrile (1:1) (10 ml) is stirred at room temperature for 30 minutes. The resultant precipitate is filtered, washed with chloroform/acetonitrile (1:1) and dried under vacuum to yield the titled compound as a white solid.

Provenance & Evidence