3-Quinuclidinol, (-)- → HCID 86627861, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (R)-1-aza-bicyclo[2.2.2]octan-3-ol (0.267 g, 2.1 mmol) in chloroform/acetonitrile (1:1) (4 ml) is added 2-bromo-N-isoxazol-3-yl-propionamide [G(i)](0.5 g, 2.28 mmol) and the reaction mixture heated in a microwave at 90° C. for 3 hours. Purification using C-18 reverse phase column chromatography (eluent: water-acetonitrile) yields the titled compound.

Provenance & Evidence