Cyclohexylphenylglycolic acid, (-)- → (R)-Cyclohexyl-hydroxy-phenyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

HRID 2240310노트

반응식

HRID 2240310 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](=[O:24])[C@:11]([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)([OH:17])[C:12]1S[CH:14]=[CH:15][CH:16]=1)[CH2:2]2.[CH:25]1([C@@](O)(C2C=CC=CC=2)C(O)=O)CCCC[CH2:26]1>>[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](=[O:24])[C@:11]([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)([OH:17])[C:12]1[CH:26]=[CH:25][CH:14]=[CH:15][CH:16]=1)[CH2:2]2

참가 물질

3

반응물 2

HCID 777377Cyclohexylphenylglycolic acid, (-)-HCID 66959049(S)-cyclohexyl-hydroxy-thiophen-2-yl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

생성물 1

HCID 10831243(R)-Cyclohexyl-hydroxy-phenyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

실험 절차

This compound is prepared analogously to (S)-cyclohexyl-hydroxy-thiophen-2-yl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester by replacing (S)-cyclohexyl-hydroxy-thiophen-2-yl-acetic acid with (R)-cyclohexyl-hydroxy-phenyl-acetic acid.

출처 및 근거

ORD 기록
ord-8b2d9217e4f14f5095ac4698a6d34a51
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723356B2

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