HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylphenylglycolic acid, (-)- → alpha-Cyclopentylmandelic acid, (+)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylphenylglycolic acid, (-)- | HCID 777377 | — |
| Reactant | (2R,5S)-2-t-Butyl-5-(1-hydroxycyclopentyl)-5-phenyl-1,3-dioxolan-4-one | HCID 11695185 | — |
| Product | alpha-Cyclopentylmandelic acid, (+)- | HCID 948620 | — |
Reaction Steps
This compound is prepared analogously to (R)-cyclohexyl-hydroxy-phenyl-acetic acid (Intermediate Siv) by replacing (2R,5S)-2-tert-butyl-5-(1-hydroxy-cyclohexyl)-5-phenyl-[1,3]dioxolan-4-one (step Siii) with (2R,5S)-2-tert-butyl-5-(1-hydroxy-cyclopentyl)-5-phenyl-[1,3]dioxolan-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723356B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-f98da41e205c4268ae4d28eda8980755 |
| Source note | uspto-grants-2010_05 |