Hydroxy[bis(4-methylphenyl)]acetic acid → (R)-3-(2-Hydroxy-2,2-di-p-tolyl-acetoxy)-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide

Participants

Role	Name	HCID	Charge
Reactant	Hydroxy[bis(4-methylphenyl)]acetic acid	HCID 229097	—
Reactant	(R)-3-[2,2-Bis-(2-chloro-phenyl)-2-hydroxy-acetoxy]-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide	HCID 11534561	—
Product	(R)-3-(2-Hydroxy-2,2-di-p-tolyl-acetoxy)-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide	HCID 11570477	—

Reaction Steps

This compound is prepared analogously to (R)-3-[2,2-bis-(2-chloro-phenyl)-2-hydroxy-acetoxy]-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide [Example 1] by substituting bis-(2-chloro-phenyl)-hydroxy-acetic acid with hydroxy-di-p-tolyl-acetic acid (Intermediate B).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07723356B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-de04ec3356344fd581e736075b28a0a6
Source note	uspto-grants-2010_05