HRID2240322

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(C(O)(C(=O)O[C@H]2C[N+]3(CC(=O)Nc4ccon4)CCC2CC3)c2ccccc2)cc1.[Br-]

HCID11671405

未命名化合物

结构：COc1ccc(C(O)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)cc1

HCID86627868

未命名化合物

结构：Cc1ccccc1C(O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1

HCID86627869

未命名化合物

2 次

PRODUCTS

生成物

结构：Cc1ccccc1C(O)(C(=O)O[C@H]1C[N+]2(CC(=O)Nc3ccon3)CCC1CC2)c1ccccc1.[Br-]

HCID11656930

未命名化合物

PROCEDURE

实验过程

This compound is prepared using an method analogous to (R)-3-[2-hydroxy-2-(4-methoxy-phenyl)-2-phenyl-acetoxy]-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]-octane bromide (Example 22) by replacing hydroxy-(4-methoxy-phenyl)-phenyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (Intermediate O) with hydroxy-phenyl-o-tolyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (Intermediate P).

WORKUP

后处理

customThis compound is prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-98e1f22b7ed64a68a431a751b1169d30
来源数据集: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07723356B2
来源说明: uspto-grants-2010_05

反应 SMILES

[Br-:1].[OH:2][C:3]([C:30]1[CH:35]=[CH:34][C:33](OC)=[CH:32][CH:31]=1)([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:4]([O:6][C@@H:7]1[CH:12]2[CH2:13][CH2:14][N+:9]([CH2:15][C:16](=[O:23])[NH:17][C:18]3[CH:22]=[CH:21][O:20][N:19]=3)([CH2:10][CH2:11]2)[CH2:8]1)=[O:5].N12CCC(CC1)[C@@H](OC(=O)C(O)(C1C=CC(OC)=CC=1)C1C=CC=CC=1)[CH2:39]2.N12CCC(CC1)[C@@H](OC(=O)C(O)(C1C=CC=CC=1)C1C=CC=CC=1C)C2>>[Br-:1].[OH:2][C:3]([C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH3:39])[C:4]([O:6][C@@H:7]1[CH:12]2[CH2:11][CH2:10][N+:9]([CH2:15][C:16](=[O:23])[NH:17][C:18]3[CH:22]=[CH:21][O:20][N:19]=3)([CH2:14][CH2:13]2)[CH2:8]1)=[O:5]