Isopropyl chloroformate → HCID 178449782, compound

Participants

Reaction Steps

Into a 50 ml round bottomed flask were added 6-[(2-methylpropyl)amino]-1,3-benzothiazole-2-thiol (100 mg, 0.42 mmol), acetone (10 ml), N,N-diisopropylethylamine (54.2 mg, 0.42 mmol) and isopropyl chloroformate (51.5 mg, 0.42 mmol). The reaction mixture was stirred for 10 h, filtered, and the solid that was obtained was triturated with diethyl ether to afford 30 mg (59%) of the title compound. 1H NMR (DMSO-d6) δ=0.80 (d, 6H), 1.11 (d, 6H), 1.60 (m, 1H), 3.43 (d, 2H), 4.76 (m, 1H), 7.24 (br s, 2H), 7.60 (s, 1H); ESIMS: m/z 323 (M−H).

Provenance & Evidence