3-Cyano-2-fluoropyridine → 2-(6-Chloro-5-fluoro-pyridin-3-yloxy)-nicotinonitrile

HRID 2240357Notes

Reaction equation

HRID 2240357 reaction equation
F[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[Cl:10][C:11]1[N:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=1[F:18]>>[Cl:10][C:11]1[N:16]=[CH:15][C:14]([O:17][C:2]2[N:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])=[CH:13][C:12]=1[F:18]

Participants

3

Reactant 2

HCID 27832543-Cyano-2-fluoropyridineHCID 404247372-Chloro-3-fluoro-5-hydroxypyridine

Product 1

HCID 860822952-(6-Chloro-5-fluoro-pyridin-3-yloxy)-nicotinonitrile

Procedure

2-Fluoro-nicotinonitrile was reacted with 6-chloro-5-fluoro-pyridin-3-ol according to the method of Example 85A to provide the title compound. MS (DCI/NH3) m/z 250 (M)+, 252 (M+2)+.

Sources & evidence

ORD record
ord-737549ccac0d4de6939916e1fd5904f2
Source dataset
uspto-grants-2010_05
Patent number
US07723367B2

Reaction notes

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