Thionyl Chloride → 4-(Azidomethyl)-3-fluoropyridine

HRID 2240387Notes

Reaction equation

HRID 2240387 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8]O.S(Cl)(Cl)=O.[N-:14]=[N+:15]=[N-:16].[Na+]>>[N:14]([CH2:8][C:7]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[F:1])=[N+:15]=[N-:16]

Participants

4

Reactant 3

HCID 24386Thionyl ChlorideHCID 33557Sodium AzideHCID 49760376(3-Fluoropyridin-4-yl)methanol

Product 1

HCID 860822684-(Azidomethyl)-3-fluoropyridine

Procedure

The product of Example 129B, thionyl chloride and sodium azide were processed according to the method of Example 115A to provide the product. MS (ESI+) m/z 153 (M+H)+.

Workup

  1. customto provide the product

Sources & evidence

ORD record
ord-d00ca77a2e334c089ac7fd32dbecc68e
Source dataset
uspto-grants-2010_05
Patent number
US07723367B2

Reaction notes

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