4,5-Difluoro-2-(pyridin-2-yloxy)benzonitrile → 1-[4,5-Difluoro-2-(pyridin-2-yloxy)phenyl]methanamine

HRID 2240395Notes

Reaction equation

HRID 2240395 reaction equation
[F:1][C:2]1[C:9]([F:10])=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH:3]=1>[Ni]>[F:1][C:2]1[C:9]([F:10])=[CH:8][C:5]([CH2:6][NH2:7])=[C:4]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH:3]=1

Participants

3

Reactant 1

HCID 685833614,5-Difluoro-2-(pyridin-2-yloxy)benzonitrile

Product 1

HCID 685825861-[4,5-Difluoro-2-(pyridin-2-yloxy)phenyl]methanamine

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

The product of Example 136B and Raney/nickel were processed according to the method of Example 131C to provide the product. MS (ESI+) m/z 237 (M+H)+;

Workup

  1. customto provide the product

Sources & evidence

ORD record
ord-b736c51abafd48b2b2c03e6b49745622
Source dataset
uspto-grants-2010_05
Patent number
US07723367B2

Reaction notes

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