Barium Sulfate → HCID 44446808, compound

HRID 2240504Notes

Reaction equation

HRID 2240504 reaction equation
[OH:1][NH:2][C:3]([C@H:5]1[CH2:12][C:9]2([NH:11][CH2:10]2)[CH2:8][CH2:7][C@@H:6]1[C:13]([N:15]1[CH2:20][CH:19]=[C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]([CH3:29])[CH3:28])[CH:22]=2)[CH2:17][CH2:16]1)=[O:14])=[O:4].[O-]S([O-])(=O)=O.[Ba+2]>CO>[OH:1][NH:2][C:3]([C@H:5]1[CH2:12][C:9]2([CH2:7][CH2:8]2)[CH2:10][NH:11][C@@H:6]1[C:13]([N:15]1[CH2:20][CH2:19][CH:18]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]([CH3:29])[CH3:28])[CH:22]=2)[CH2:17][CH2:16]1)=[O:14])=[O:4]

Participants

4

Reactant 2

HCID 24414Barium SulfateHCID 86761114HCID 86761114, compound

Product 1

HCID 44446808HCID 44446808, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(6S,7S)-N-hydroxy-6-{[4-(3-isopropylphenyl)-3,6-dihydropyridin-1(2H)-yl]carbonyl}- -azaspiro[2.5]octane-7-carboxamide (10 mg) was hydrogenated at 1.0 atm over BaSO4 in MeOH for one hour to give the desired product, Ms(ESI): (M+H)+=400.4.

Sources & evidence

ORD record
ord-f3eedfeac7f14ae2b4f1ea11a9f457ea
Source dataset
uspto-grants-2010_05
Patent number
US07723349B2

Reaction notes

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