Iodine → {3-[(2,6-Dichlorophenyl)sulfanyl]-2,5-dimethyl-1H-indol-1-yl}acetic acid

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Reaction Steps

Iodine (0.51 g) was added to a solution of 2,6-dichlorobenzenethiol (0.36 g) and the product from example 13 step a) (0.2 g) in DMF (5 ml). After 1 h the solution was purified by reverse phase HPLC. The solvent was evaporated in vacuo and the oily residue treated with ether to give a solid. Filtered off and dried to yield the title compound as a white solid (0.22 g).

Provenance & Evidence