HCID 57443411, compound → HCID 57443412, compound

Participants

Reaction Steps

324 mg of the compound (1c) (0.933 mM) prepared by the above Step 2 was added to the catalyst solution containing 74 mg of ruthenium (0.09 mM) dissolved in 93 ml of CH2Cl2. Then the mixture was stirred for 24 hrs at room temperature, filtered and concentrated in vacuo. The resultant was purified by Silica gel column chromatography with a solvent mixture mixed with EtOAc and hexanes (1:1) as an eluant to give 268 mg of 3-[1-(2,4-dimethoxybenzyl)-2-oxo-2,5-dihydro-1H-pyrole-3-yl]-propionic acid methyl ester (1d) (yield: 90%).

Provenance & Evidence