反应详情

30 mg of (1-benzyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-acetic acid methyl ester was dissolved in methanol solution (0.12 mM) under nitrogen atmosphere. Then 2.6 mg of Pd—C (0.02 mM) was added thereto, and hydrogenated under a hydrogen balloon for 1 to 2 hrs at room temperature. The reaction mixture was filtered and concentrated in vacuo. The resulting compound was purified with Silica gel column chromatography with a solvent mixture mixed with EtOAc and hexane (1:1) as an eluant to give (2-oxo-1-phenethyl-pyrrolidin-3-yl)-acetic acid methyl ester (25r) (yield: 95%).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated in vacuo
3. customThe resulting compound was purified with Silica gel column chromatography with a solvent mixture
4. additionmixed with EtOAc and hexane (1:1) as an eluant