反应详情

1.39 g of 3-p-tolyl-acrylic acid methyl ester (40aa) prepared by above Step 1 was dissolved in methanol solution (7.9 mM) under nitrogen atmosphere. Then Pd—C was added thereto, hydrogenated under a hydrogen balloon for 1 to 2 hrs at room temperature. The reaction mixture was filtered and concentrated in vacuo. The resulting compound was purified with Silica gel column chromatography with a solvent mixture mixed with EtOAc and hexane (1:10) as an eluant to give 1.24 g of 3-p-tolyl-propionic acid methyl ester (40ab) (yield: 95%).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated in vacuo
3. customThe resulting compound was purified with Silica gel column chromatography with a solvent mixture
4. additionmixed with EtOAc and hexane (1:10) as an eluant