HCID 57443422, compound → HCID 67453428, compound

Participants

Reaction Steps

797 mg of 4-[allyl-(3-p-tolyl-propyl)-carbamoyl]-pent-4-enoic acid methyl ester (40af) (2.6 mM) prepared by the above Step 6 was added to the catalyst solution containing 180 mg of ruthenium catalyst (0.1 mM) dissolved in 200 ml of CH2Cl2 under Ar atmosphere. Then the mixture was stirred for 24 hrs at room temperature, filtered and concentrated in vacuo. The resultant was purified by Silica gel column chromatography with a solvent mixture mixed with EtOAc and hexanes (1:1) as an eluant to give 391 mg of 3-[2-oxo-1-(3-p-tolyl-propyl)-2,5-dihydro-1H-pyrrol-3-yl]-propionic acid methyl ester (40ag) (yield: 50%).

Provenance & Evidence