HCID 57443431, compound → HCID 57443430, compound

HRID 2240603Notes

Reaction equation

HRID 2240603 reaction equation
[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[C:6](=[O:22])[N:7]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=2[O:20][CH3:21])[CH2:8][CH2:9][CH:10]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:23])[CH2:4][CH:5]1[CH2:10][CH2:9][CH2:8][N:7]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=2[O:20][CH3:21])[C:6]1=[O:22]

Participants

4

Reactant 1

HCID 57443431HCID 57443431, compound

Product 1

HCID 57443430HCID 57443430, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

26 mg of [1-(2,4-dimethoxy-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-acetic acid methyl ester (o) (0.08 mM) was dissolved in methanol solution under Ar atmosphere. 1.7 mg of 10% Pd—C was added thereto and the mixture was hydrogenated under a hydrogen balloon. The reaction mixture was stirred for 5 hrs at room temperature, filtered and concentrated in vacuo. The resulting compound was purified with Silica gel column chromatography to give 25 mg of [1-(2,4-dimethoxy-benzyl)-2-oxo-piperidine-3-yl]acetic acid methyl ester (r) (yield: 99%).

Workup

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo
  3. customThe resulting compound was purified with Silica gel column chromatography

Sources & evidence

ORD record
ord-cc48cf17483245fb9df86f7bbc67e0c8
Source dataset
uspto-grants-2010_05
Patent number
US07723376B2

Reaction notes

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