2-Tert-butyl-4-isopropyl-6-piperazin-1-ylpyrimidine → 1-{4-[4-(2-tert-Butyl-6-isopropylpyrimidin-4-yl) piperazin-1-yl]butyl}-3,4-dihydro-1H-1-benzazepine-2,5-dione

HRID 2240623Notes

Reaction equation

HRID 2240623 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([CH:11]([CH3:13])[CH3:12])[CH:8]=[C:7]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl[CH2:21][CH2:22][CH2:23][CH2:24][N:25]1[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=2[C:29](=[O:36])[CH2:28][CH2:27][C:26]1=[O:37]>>[C:1]([C:5]1[N:6]=[C:7]([N:14]2[CH2:15][CH2:16][N:17]([CH2:21][CH2:22][CH2:23][CH2:24][N:25]3[C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=4[C:29](=[O:36])[CH2:28][CH2:27][C:26]3=[O:37])[CH2:18][CH2:19]2)[CH:8]=[C:9]([CH:11]([CH3:13])[CH3:12])[N:10]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 672432152-Tert-butyl-4-isopropyl-6-piperazin-1-ylpyrimidineHCID 685828961-(4-chlorobutyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 685839211-{4-[4-(2-tert-Butyl-6-isopropylpyrimidin-4-yl) piperazin-1-yl]butyl}-3,4-dihydro-1H-1-benzazepine-2,5-dione

Procedure

Analogously to Example 3b, reaction of 2-tert-butyl-4-isopropyl-6-piperazin-1-ylpyrimidine (0.95 mmol, 0.25 g) with 1-(4-chlorobutyl)-3,4-dihydro-1H-1-benzazepine-2,5-dione afforded 0.04 g of the title compound.

Sources & evidence

ORD record
ord-01fdda7aacf44bdea9d443eae3693faf
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

Loading…