Sodium Hydroxide → HCID 68583274, compound

HRID 2240628Notes

Reaction equation

HRID 2240628 reaction equation
[O:1]=[C:2]1[N:8]([CH2:9][CH2:10][CH2:11][C:12]([O:14]C)=[O:13])[C:7]2[CH:16]=[CH:17][CH:18]=[CH:19][C:6]=2[C:5](=[O:20])[CH2:4][CH2:3]1.[OH-].[Na+]>O.CO>[O:1]=[C:2]1[N:8]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])[C:7]2[CH:16]=[CH:17][CH:18]=[CH:19][C:6]=2[C:5](=[O:20])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68584241HCID 68584241, compound

Product 1

HCID 68583274HCID 68583274, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Methyl 4-(2,5-dioxo-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl)butanoate from step a (100 mg, 0.36 mmol) in water/methanol (0.7:2.0 ml) was treated with NaOH (1N, 0.80 ml) to obtain 63.0 mg of 4-(2,5-dioxo-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl)butanoic acid.

Sources & evidence

ORD record
ord-ebd182af3bf746909c8d36ecc511e265
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

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