反应详情

温度

0 °C

3 g of tert-butyl 4-(1-aminocyclopropyl)benzoate was placed in 30 mL of dichloromethane and 1.8 mL of pyridine. The solution was cooled to 0° C. and 1.2 mL of allyl chloroformate (dissolved in 5 mL of dichloromethane) was added dropwise at 0° C.-5° C. The mixture was left to react for 30 minutes at 0° C. and 2 hours at RT. The solution was combined with silica gel and evaporated down to the residue. This was chromatographed with dichloromethane on silica gel 70. Yield: 1.46 g of oil.

1. waitThe mixture was left
2. customto react for 30 minutes at 0° C. and 2 hours at RT
3. customevaporated down to the residue
4. customThis was chromatographed with dichloromethane on silica gel 70