Bromine → HCID 86643648, compound

HRID 2240647Notes

Reaction equation

HRID 2240647 reaction equation
[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16](=[O:27])[NH:17][CH:18]3[CH2:23][CH2:22][CH:21]([C:24](=[O:26])[CH3:25])[CH2:20][CH2:19]3)[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[Br:28]Br>CO>[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16](=[O:27])[NH:17][CH:18]3[CH2:23][CH2:22][CH:21]([C:24](=[O:26])[CH2:25][Br:28])[CH2:20][CH2:19]3)[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 69108330HCID 69108330, compound

Product 1

HCID 86643648HCID 86643648, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7.77 g (21 mmol) of 9H-fluoren-9-ylmethyl(4-acetylcyclohexyl)carbamate (cis compound) is dissolved in 100 mL of methanol at ambient temperature and combined with 1.09 mL (21 mmol) of bromine. The mixture is stirred for 16 hours at ambient temperature, cooled, and the crystals precipitated are suction filtered. Yield: 6.35 g (50%); NMR: LG201641.

Workup

  1. temperaturecooled
  2. customthe crystals precipitated

Sources & evidence

ORD record
ord-e74d5a576ab741ebbb017754beebb9fb
Source dataset
uspto-grants-2010_05
Patent number
US07723381B2

Reaction notes

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