Cyclohexanol → HCID 59305391, compound

HRID 2240661Notes

Reaction equation

HRID 2240661 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:41]=[CH:40][C:11]([CH2:12][C:13]3[N:14]([C:26]4[CH:31]=[CH:30][C:29]([N:32]5[S:36](=[O:38])(=[O:37])[NH:35][C:34](=[O:39])[CH2:33]5)=[CH:28][CH:27]=4)[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=4[Cl:25])[N:17]=3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH:42]1([OH:48])[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]1>>[CH:42]1([O:48][C:2]2[N:7]=[CH:6][C:5]([C:8]3[CH:9]=[CH:10][C:11]([CH2:12][C:13]4[N:14]([C:26]5[CH:27]=[CH:28][C:29]([N:32]6[S:36](=[O:38])(=[O:37])[NH:35][C:34](=[O:39])[CH2:33]6)=[CH:30][CH:31]=5)[CH:15]=[C:16]([C:18]5[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=5[Cl:25])[N:17]=4)=[CH:40][CH:41]=3)=[CH:4][CH:3]=2)[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]1

Participants

3

Reactant 2

HCID 7966CyclohexanolHCID 59305413HCID 59305413, compound

Product 1

HCID 59305391HCID 59305391, compound

Procedure

5-{4-[2-[4-(6-Chloro-pyridin-3-yl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide (63 mg, 0.1 mmol) was treated as described in general procedure L using cyclohexanol (20 mg, 0.2 mmol) to give 5-{4-[2[4-(6-cyclohexyloxy-pyridin-3-yl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide.

Sources & evidence

ORD record
ord-425fb82cbb8544cd91be32072ff9a448
Source dataset
uspto-grants-2010_05
Patent number
US07723369B2

Reaction notes

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