4-Cyclohexylbenzeneboronic acid → HCID 59305445, compound

HRID 2240664Notes

Reaction equation

HRID 2240664 reaction equation
Br[C:2]1[CH:36]=[CH:35][C:5]([CH2:6][C:7]2[N:8]([C:20]3[CH:25]=[CH:24][C:23]([N:26]4[S:30](=[O:32])(=[O:31])[NH:29][C:28](=[O:33])[CH2:27]4)=[C:22]([CH3:34])[CH:21]=3)[CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=3[Cl:19])[N:11]=2)=[CH:4][CH:3]=1.[CH:37]1([C:43]2[CH:48]=[CH:47][C:46](B(O)O)=[CH:45][CH:44]=2)[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]1>>[CH:43]1([C:37]2[CH:38]=[CH:39][C:40]([C:2]3[CH:36]=[CH:35][C:5]([CH2:6][C:7]4[N:8]([C:20]5[CH:25]=[CH:24][C:23]([N:26]6[S:30](=[O:31])(=[O:32])[NH:29][C:28](=[O:33])[CH2:27]6)=[C:22]([CH3:34])[CH:21]=5)[CH:9]=[C:10]([C:12]5[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=5[Cl:19])[N:11]=4)=[CH:4][CH:3]=3)=[CH:41][CH:42]=2)[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48]1

Participants

3

Reactant 2

HCID 45891894-Cyclohexylbenzeneboronic acidHCID 68584484HCID 68584484, compound

Product 1

HCID 59305445HCID 59305445, compound

Procedure

5-{4-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-2-methyl-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide (61 mg, 0.1 mmol) was treated as described in general procedure G using 4-cyclohexylphenylboronic acid (41 mg, 0.2 mmol) to give 5-{4-[2-(4′-cyclohexyl-biphenyl-4-ylmethyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-2-methyl-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide.

Sources & evidence

ORD record
ord-f32182e825e34024af8945133e156400
Source dataset
uspto-grants-2010_05
Patent number
US07723369B2

Reaction notes

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