4-Cyclohexylbenzeneboronic acid → HCID 68584449, compound

HRID 2240723Notes

Reaction equation

HRID 2240723 reaction equation
[CH3:1][O:2][C:3](=[O:35])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([CH2:27][C:28]3[CH:33]=[CH:32][C:31](Br)=[CH:30][CH:29]=3)[N:13]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])=[CH:17][CH:16]=3)[CH:14]=2)=[CH:6][CH:5]=1.[CH:36]1([C:42]2[CH:47]=[CH:46][C:45](B(O)O)=[CH:44][CH:43]=2)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1>>[CH3:1][O:2][C:3](=[O:35])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([CH2:27][C:28]3[CH:33]=[CH:32][C:31]([C:39]4[CH:38]=[CH:37][C:36]([CH:42]5[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]5)=[CH:41][CH:40]=4)=[CH:30][CH:29]=3)[N:13]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])=[CH:17][CH:16]=3)[CH:14]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 45891894-Cyclohexylbenzeneboronic acidHCID 68582900HCID 68582900, compound

Product 1

HCID 68584449HCID 68584449, compound

Procedure

4-{2-(4-Bromo-benzyl)-1-[4-(methoxycarbonylmethyl-amino)-phenyl]-1H-imidazol-4-yl}-benzoic acid methyl ester (2.7 g, 5 mmol) was coupled with 4-cyclohexyl-phenylboronic acid (1.25 g, 6.0 mmol) according to general procedure G to give 4-{2-(4′-cyclohexyl-biphenyl-4-ylmethyl)-1-[4-(methoxycarbonylmethyl-amino)-phenyl]-1H-imidazol-4-yl}-benzoic acid methyl ester.

Sources & evidence

ORD record
ord-1702f07918c84c69a88f95b0ad0dfb61
Source dataset
uspto-grants-2010_05
Patent number
US07723369B2

Reaction notes

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