p-Fluoronitrobenzene → HCID 68583276, compound

HRID 2240726Notes

Reaction equation

[Br:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][C:7]2[NH:8][CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=3)[N:11]=2)=[CH:4][CH:3]=1.F[C:25]1[CH:30]=[CH:29][C:28]([N+:31]([O-:33])=[O:32])=[CH:27][CH:26]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]2[N:8]([C:25]3[CH:30]=[CH:29][C:28]([N+:31]([O-:33])=[O:32])=[CH:27][CH:26]=3)[CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:21])[F:20])=[CH:14][CH:13]=3)[N:11]=2)=[CH:22][CH:23]=1

Participants

Reactant 2

HCID 9590p-Fluoronitrobenzene

HCID 178506114HCID 178506114, compound

Product 1

HCID 68583276HCID 68583276, compound

Procedure

2-(4-Bromo-benzyl)-4-(4-trifluoromethyl-phenyl)-1H-imidazole (9.6 g, 25 mmol) was treated as described in general procedure B using 1-fluoro-4-nitrobenzene to give 2-(4-bromo-benzyl)-1-(4-Nitro-phenyl)-4-(4-trifluoromethyl-phenyl)-1H-imidazole.

Sources & evidence

ORD record: ord-836f491838964067bb31557c8ca6c3a7
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07723369B2

Reaction notes

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