Acetaldehyde → HCID 59305476, compound

HRID 2240736Notes

Reaction equation

HRID 2240736 reaction equation
[CH:1]1([CH2:7][NH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][C:22]4[N:23]([C:35]5[CH:36]=[C:37]([N:41]6[S:45](=[O:47])(=[O:46])[NH:44][C:43](=[O:48])[CH2:42]6)[CH:38]=[CH:39][CH:40]=5)[CH:24]=[C:25]([C:27]5[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=5[Cl:34])[N:26]=4)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:49](=O)[CH3:50]>>[CH:1]1([CH2:7][N:8]([CH2:49][CH3:50])[C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:16]=[CH:17][C:18]([CH2:21][C:22]4[N:23]([C:35]5[CH:36]=[C:37]([N:41]6[S:45](=[O:47])(=[O:46])[NH:44][C:43](=[O:48])[CH2:42]6)[CH:38]=[CH:39][CH:40]=5)[CH:24]=[C:25]([C:27]5[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=5[Cl:34])[N:26]=4)=[CH:19][CH:20]=3)=[CH:13][CH:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 177AcetaldehydeHCID 59305522HCID 59305522, compound

Product 1

HCID 59305476HCID 59305476, compound

Procedure

5-{3-[2-[4′-(Cyclohexylmethyl-amino)-biphenyl-4-ylmethyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-[1,2,5]thiadiazolidin-3-one-1,1-dioxide (7 mg, 0.01 mmol) was reacted with acetaldehyde (2 mg, 0.04 mmol) following general procedure X to give 5-{3-[2-[4′-(cyclohexylmethyl-ethyl-amino)-biphenyl-4-ylmethyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide.

Sources & evidence

ORD record
ord-47fbb23c233b416295806aa4b0369d39
Source dataset
uspto-grants-2010_05
Patent number
US07723369B2

Reaction notes

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