p-Fluoronitrobenzene → HCID 68582533, compound

HRID 2240754Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]([CH2:14][C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:25][CH3:26])[CH:21]=3)[CH:16]=2)[NH:12][CH:13]=1.F[C:28]1[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][CH:29]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]([CH2:14][C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:25][CH3:26])[CH:21]=3)[CH:16]=2)[N:12]([C:28]2[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][CH:29]=2)[CH:13]=1

Participants

Reactant 2

HCID 9590p-Fluoronitrobenzene

HCID 178487431HCID 178487431, compound

Product 1

HCID 68582533HCID 68582533, compound

Procedure

4-(2,4-Dichloro-phenyl)-2-(6-methoxy-naphthalen-2-ylmethyl)-1H-imidazole (383 mg, 1 mmol) was treated as described in general procedure B using 1-fluoro-4-nitrobenzene to give 4-(2,4-dichloro-phenyl)-1-(4-nitro-phenyl)-2-(6-methoxy-naphthalen-2-ylmethyl)-1H-imidazole.

Sources & evidence

ORD record: ord-40368153f23943c1b9ba1ef2c2fa86da
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07723369B2

Reaction notes

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